The role of genetic factors in the aetiology of achalasia

Completed

• Conditions: Achalasia; Oesophageal motility disorder; 10017977; 10029317

• Registration Number: NL-OMON39386
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 450

Inclusion Criteria

- Diagnosis of idiopathic achalasia confirmed by oesophageal manometry that show the following criteria:
- Aperistalsis or simultaneous contractions in the oesophageal body.
- LOS dysrelaxation.
- Age *18 years.
- Written informed consent.

Exclusion Criteria

- Having a medical or mental contradictory condition to participate in the study, even after agreeing to participate.
- Pseudoachalasia.
- Upper gastrointestinal malignancy.
- Chagas disease.
- Previous allogeneic bone marrow transplant.
- Non leukocyte depleted whole blood transfusion within 120 days of the date of genetic sample collection.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Genetic variants associated with achalasia.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Demographic and clinical data on idiopathic achalasia.</p><br>