The Effects of Six-week Hydrogen Plus Pyrroloquinoline Quinone (PQQ) Intake on Mitochondrial Biomarkers, Brain Metabolism and Cognition in the Elderly With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Fibroblast growth factor 21
研究概览
简要总结
The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of dietary supplementation with molecular hydrogen and pyrroloquinoline quinone in elderly. The main questions it aims to answer are: (1) whether the supplementation affects biomarkers of mitochondrial function in serum, and (2) whether the supplementation affects cognition and brain metabolism. The participants will be subjected to take the dietary supplement during 6 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 65 years
- •MMSE scores ranged from 23-27
- •Informed consent signed
排除标准
- •Take part in exercise on a regular basis
- •Severe chronic disease and acute injuries
- •History of dietary supplement use during the past 4weeks
- •No consent to randomization
- •Participation in other studies
研究组 & 干预措施
Supplement
One tablet of supplement before breakfast and dinner
干预措施: Supplement (Dietary Supplement)
Placebo
One tablet of inert compound before breakfast and dinner
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Fibroblast growth factor 21
时间窗: Change from baseline serum fibroblast growth factor 21 at 6 weeks
Level of fibroblast growth factor 21 in serum
次要结局
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(Change from baseline serum peroxisome proliferator-activated receptor gamma coactivator 1-alpha at 6 weeks)
- Brain creatine(Change from baseline brain creatine at 6 weeks)
- Brain-derived neurotrophic factor(Change from baseline serum brain-derived neurotrophic factor at 6 weeks)
- Irisin(Change from baseline serum irisin at 6 weeks)
- General cognition(Change from baseline MMSE score at 6 weeks)
- Brain oxygenation(Change from baseline brain oxygenation at 6 weeks)
研究者
Sergej Ostojic
Professor
University of Novi Sad, Faculty of Sport and Physical Education