Metabolic Dynamics During Physical Activity

Not Applicable

Completed

• Conditions: Healthy Men and Women
• Interventions: Other: running on a treadmill under normoxia or hypoxia

• Registration Number: NCT03485716
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-01
• Primary Completion: 2017-03-31
• Study Completion: 2017-12-31
• Status Verified: 2018-03
• Study First Submitted: 2018-03-19
• Study First Submitted QC: 2018-03-30
• Last Update Submitted: 2018-03-30
• Study First Posted: 2018-04-02
• Last Update Posted: 2018-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• healthy volunteers
• written informed consent

Exclusion Criteria

• known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases
• pregnancy, lactating period
• unability to understand study content and aims and to give written informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
running under hypoxia - first	running on a treadmill under normoxia or hypoxia	running under hypoxia (first day) and normoxia (second day)
running under normoxia - first	running on a treadmill under normoxia or hypoxia	running under normoxia (first day) and hypoxia (second day)

Primary Outcome Measures

Name	Time	Method
Change in capillary lactate/pyruvate Ratio (dimension-free)	t = 0 min (before exercise); t = 10, 20 and 30 min during exercise; t = 50 and 60 min during recovery	marker for the ratio between anaerobic / aerobic glycolysis

Trial Locations

Locations (1)

Charite University Medicine, ECRC; 🇩🇪 Berlin, Germany