Time-course of CNS cytokine concentrations after elective orthopedic procedures in the elderly and their possible role as biomarkers for delirium

Recruiting

• Conditions: F05.0; F05.1; Delirium not superimposed on dementia, so described; Delirium superimposed on dementia

• Registration Number: DRKS00004413
• Lead Sponsor: Klinik für Anästhesie und operative Intensivmedizin, St. Franziskus-Hospital Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

elective major orthopedic surgery (hip replacement); normal preoperative scores in MMST; normal preoperative scores in CAM

Exclusion Criteria

non-elective surgery; MMST or IQCODE or CAM indicating cognitive impairment or preexisting delirium

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time-course of cytokine concentrations in CSF and blood (before surgery and on first and second day post OP)

Secondary Outcome Measures

Name	Time	Method
Delirium; further postoperative complications; death; lung emboly; pain; heart failure; apoplexia. Routine examinations of blood, visual analogue scale (VAS - twice a day - pain) and Confusion Assessment Method (CAM - twice a day - delirium)