Studies of Neurological Paraneoplastic Syndromes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Increase understanding of PNDS
研究概览
简要总结
This study is for patients with cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome.
详细描述
Patients usually go to their doctors with neurological complaints and later find they have cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome. Paraneoplastic syndromes are rare conditions in which the immune system is involved in causing brain damage and fighting cancer.
Such patients with paraneoplastic neurologic degenerations(PNDs) may have autoantibodies, an antibody or protein the immune system creates that is directed against his or her own proteins. This study aims to better understand PNDS by:
- analyzing for autoantibodies in serum and cerebral spinal fluid
- analyzing for antigen specificity and for antigens in cancer tissue
- comparing PND autoantibodies with those in cancer patients but no PND
- comparing PND autoantibodies with those in PND patients but no cancer
- studying the immune performance of patients with PNDs
As this study is not a treatment study, tissues for this study will only come from procedures necessary for the patient's treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adults are potentially eligible.
排除标准
- 未提供
结局指标
主要结局
Increase understanding of PNDS
时间窗: Ongoing
次要结局
未报告次要终点