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Plasmakinetics of gamma-aminobutyric acid from tomatoes as compared to a supplement, after a single oral administration in healthy young me

Completed
Conditions
Voedingsonderzoek
plasmakinetics of GABA
Registration Number
NL-OMON48303
Lead Sponsor
Wageningen Universiteit
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
Not specified
Target Recruitment
12
Inclusion Criteria

- BMI between 18.5 and 25 kg/m2
- Age is between 18 and 28 years
- Good general health
- Male
- Veins suitable for blood sampling
- Able to speak Dutch

Exclusion Criteria

- Is currently suffering from a disease including mental disorders
- Has had any gastrointestinal condition/disease within the 3 months prior to
the intervention
- Haemoglobin (Hb) level < 8.5 mmol/L
- Has used medication in the two months before and/or during the intervention.
Occasional use of NSAIDs or paracetamol (- Reported weight loss or weight gain of > 2 kg in the month prior to the
intervention
- Use of dietary supplements, 3 weeks before-, or during the intervention.
- Allergic to products that are provided as part of the standardised diet
- Following a specific diet (e.g. vegetarian, gluten free)
- Allergic to tomatoes
- (History of) drug abuse, in this case meaning >1 x per month use of
recreational drugs
- Smoking
- Alcohol consumption of >10 standardised glasses per week.
- Recent or planned blood donation (<3 month prior to first study day or during
intervention)
- Personnel of Wageningen University, department of Human Nutrition and Health,
- Currently participating in other research or was participating in another
study within 1 month of the intervention or within 3 months if invasive
procedures were used.

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
<p>The main study outcome is the plasma-time curve of GABA. This will be evaluated<br /><br>using descriptive kinetics: maximum peak height (Cmax), time-to-peak (Tmax),<br /><br>and area-under-the-curve (AUC).</p><br>
Secondary Outcome Measures
NameTimeMethod
<p>- To evaluate the effects of an oral GABA dose and tomatoes on the plasma<br /><br>concentrations of glutamate in healthy men.<br /><br>- To evaluate the effects of a single oral glutamate dose on the plasma<br /><br>concentrations of GABA and compare this to the plasma concentrations of GABA<br /><br>after the intake of a tomatoes.</p><br>
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