Plasmakinetics of gamma-aminobutyric acid from tomatoes as compared to a supplement, after a single oral administration in healthy young me
- Conditions
- Voedingsonderzoekplasmakinetics of GABA
- Registration Number
- NL-OMON48303
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
- BMI between 18.5 and 25 kg/m2
- Age is between 18 and 28 years
- Good general health
- Male
- Veins suitable for blood sampling
- Able to speak Dutch
- Is currently suffering from a disease including mental disorders
- Has had any gastrointestinal condition/disease within the 3 months prior to
the intervention
- Haemoglobin (Hb) level < 8.5 mmol/L
- Has used medication in the two months before and/or during the intervention.
Occasional use of NSAIDs or paracetamol (- Reported weight loss or weight gain of > 2 kg in the month prior to the
intervention
- Use of dietary supplements, 3 weeks before-, or during the intervention.
- Allergic to products that are provided as part of the standardised diet
- Following a specific diet (e.g. vegetarian, gluten free)
- Allergic to tomatoes
- (History of) drug abuse, in this case meaning >1 x per month use of
recreational drugs
- Smoking
- Alcohol consumption of >10 standardised glasses per week.
- Recent or planned blood donation (<3 month prior to first study day or during
intervention)
- Personnel of Wageningen University, department of Human Nutrition and Health,
- Currently participating in other research or was participating in another
study within 1 month of the intervention or within 3 months if invasive
procedures were used.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study outcome is the plasma-time curve of GABA. This will be evaluated<br /><br>using descriptive kinetics: maximum peak height (Cmax), time-to-peak (Tmax),<br /><br>and area-under-the-curve (AUC).</p><br>
- Secondary Outcome Measures
Name Time Method <p>- To evaluate the effects of an oral GABA dose and tomatoes on the plasma<br /><br>concentrations of glutamate in healthy men.<br /><br>- To evaluate the effects of a single oral glutamate dose on the plasma<br /><br>concentrations of GABA and compare this to the plasma concentrations of GABA<br /><br>after the intake of a tomatoes.</p><br>