Changes of the gastrointestinal microbiome in perioperative patients
- Conditions
- A41C25Z98Other sepsisMalignant neoplasm of pancreasOther postsurgical states
- Registration Number
- DRKS00008535
- Lead Sponsor
- niversitätsklinikum Heidelberg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
*Written consent form of study participant or his appointed representative
*Age > 18 years
*undergoing a whipple-operation
Exclusion Criteria
*Non-fulfillment of inclusion criteria
*chronic inflammatory diseases
*antibiotic allergies
*Refusal of participation in the study
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method *Changes in the gastrointestinal microbiome under antibiotic therapy (stool samples: preoperative, 1d, 3d, 5d, 7d)<br>*Comparison of the microbiome changes and clinical complications (preoperative, 1d, 3d, 5d, 7d)
- Secondary Outcome Measures
Name Time Method *Comparison of the micobiome changes and outcomerelevance at the timepoints: preoperative, 1d, 3d, 5d, 7d (addditionally: reevaluation: 28d, 90d)
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link gastrointestinal microbiome changes to sepsis in perioperative patients?
How does the GIMA-Trial compare to other observational studies on post-surgical microbiome alterations and pancreatic cancer outcomes?
What biomarkers are associated with favorable outcomes in patients with postsurgical states and sepsis as studied in DRKS00008535?
Are there specific adverse events linked to microbiome dysbiosis in perioperative care, and how are they managed?
What role do gut microbiota play in modulating immune responses in malignant neoplasm of the pancreas and sepsis?