Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes
- Conditions
- Pediatric Multiple Sclerosis
- Registration Number
- NCT03066752
- Lead Sponsor
- The Hospital for Sick Children
- Brief Summary
Up to 65% of patients with multiple sclerosis (MS) experience cognitive dysfunction. Diminution of mental capacity has a pervasive and profound impact on their quality of life. Subtle changes in white matter predict cognitive changes in these patients but how this disrupts brain function remains unclear. Development of effective therapeutics to restore normal cognition hinges on elucidating these functional changes. The investigators seek to uncover the patho-physiological basis for cognitive decline in MS. The investigators hypothesize that cognitive decline originates from disrupted gamma oscillations and that gamma oscillations are disrupted by molecular changes triggered by demyelination.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Neurocognitive Testing 90 minutes Penn Computerized Neurocognitive Battery
Neurological Exam - Standard physical exam performed by the neurologist to determine the Expanded Disability Status Scale (EDSS) score. 20 minutes Neuronal responses during simple and choice reaction time tasks 60 minutes Video-based eye tracking in the MEG
MRI scans of the brain, including Diffusion Tensor Imagine (DTI) 90 minutes Clinical Interview 10 minutes Series of questions about the participant's demographic and clinical information including, current and past health, family history, and medications.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada