Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Neurocognitive Testing
研究概览
简要总结
Up to 65% of patients with multiple sclerosis (MS) experience cognitive dysfunction. Diminution of mental capacity has a pervasive and profound impact on their quality of life. Subtle changes in white matter predict cognitive changes in these patients but how this disrupts brain function remains unclear. Development of effective therapeutics to restore normal cognition hinges on elucidating these functional changes. The investigators seek to uncover the patho-physiological basis for cognitive decline in MS. The investigators hypothesize that cognitive decline originates from disrupted gamma oscillations and that gamma oscillations are disrupted by molecular changes triggered by demyelination.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Neurocognitive Testing
时间窗: 90 minutes
Penn Computerized Neurocognitive Battery
Neurological Exam - Standard physical exam performed by the neurologist to determine the Expanded Disability Status Scale (EDSS) score.
时间窗: 20 minutes
Neuronal responses during simple and choice reaction time tasks
时间窗: 60 minutes
Video-based eye tracking in the MEG
MRI scans of the brain, including Diffusion Tensor Imagine (DTI)
时间窗: 90 minutes
Clinical Interview
时间窗: 10 minutes
Series of questions about the participant's demographic and clinical information including, current and past health, family history, and medications.
次要结局
未报告次要终点
研究者
E. Ann Yeh
Associate Scientist, Research Institute
The Hospital for Sick Children