跳至主要内容
临床试验/NCT03066752
NCT03066752
已完成
不适用

Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes

The Hospital for Sick Children1 个研究点 分布在 1 个国家目标入组 20 人2017年3月27日

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
Pediatric Multiple Sclerosis
发起方
The Hospital for Sick Children
入组人数
20
试验地点
1
主要终点
Neurocognitive Testing
状态
已完成
最后更新
6年前

概览

简要总结

Up to 65% of patients with multiple sclerosis (MS) experience cognitive dysfunction. Diminution of mental capacity has a pervasive and profound impact on their quality of life. Subtle changes in white matter predict cognitive changes in these patients but how this disrupts brain function remains unclear. Development of effective therapeutics to restore normal cognition hinges on elucidating these functional changes. The investigators seek to uncover the patho-physiological basis for cognitive decline in MS. The investigators hypothesize that cognitive decline originates from disrupted gamma oscillations and that gamma oscillations are disrupted by molecular changes triggered by demyelination.

注册库
clinicaltrials.gov
开始日期
2017年3月27日
结束日期
2017年11月24日
最后更新
6年前
研究类型
Observational
性别
All

研究者

责任方
Principal Investigator
主要研究者

E. Ann Yeh

Associate Scientist, Research Institute

The Hospital for Sick Children

入排标准

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Neurocognitive Testing

时间窗: 90 minutes

Penn Computerized Neurocognitive Battery

Neurological Exam - Standard physical exam performed by the neurologist to determine the Expanded Disability Status Scale (EDSS) score.

时间窗: 20 minutes

Neuronal responses during simple and choice reaction time tasks

时间窗: 60 minutes

Video-based eye tracking in the MEG

MRI scans of the brain, including Diffusion Tensor Imagine (DTI)

时间窗: 90 minutes

Clinical Interview

时间窗: 10 minutes

Series of questions about the participant's demographic and clinical information including, current and past health, family history, and medications.

研究点 (1)

Loading locations...

相似试验