Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients
- Conditions
- Non-critically Ill PatientsDiabetes Mellitus
- Interventions
- Registration Number
- NCT03510078
- Lead Sponsor
- Rabin Medical Center
- Brief Summary
Hyperglycemia is a common condition among hospitalized patients. The occurrence of severe hyperglycemia is associated with increased morbidity and mortality in several populations. Several trials assessed the benefits of aggressive versus conventional glucose control. These studies evaluated different patient populations, glucose targets and treatment protocols and as a result reported conflicting results. To date there are no clear guidelines regarding to the preferred glucose target range in hospitalized non-critically ill patients. The common practice is to maintain glucose level lower than 180 mg/dl however there are no evidence based regarding to the outcomes of hospitalized patients treated with intensive compared to conventional glycemic control. This prospective randomized controlled study will compare intensive vs. standard glycemic control in hospitalized non-critically ill patients.
Within 24 hours of hospitalization in the internal medical or geriatric departments, patients who are expected to require hospitalization for at least three consecutive days will be randomly assigned into one of the two study groups - intensive with a target blood glucose range of 130 mg per deciliter or less, or conventional glucose control, with a target of 130-180 mg per deciliter. The investigators defined the primary end point as a composite outcome of mortality in 30 days, severe hypoglycemia, severe infections within 30 days, CVA and cardiac ischemic events within 30 days.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 600
- Age older than 18 years old.
- History of type 2 diabetes mellitus for at least three months or a blood glucose level of 200 mg per deciliter or higher in two different consecutive measurements.
- A minimum of three days of hospitalization.
- Diabetic ketoacidosis or hyperosmolar non-ketotic state at any stage of hospitalization.
- Patients expected to require intensive care unit admission or immediate surgical intervention.
- History of current drug or alcohol abuse.
- History of current mental illness.
- Child-bearing potential or a positive urine pregnancy test.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Intensive glycemic control Insulin With a target of blood glucose range of 130 mg/dL or less Conventional glycemic control Insulin With a target of blood glucose range of 130-180 mg/dL
- Primary Outcome Measures
Name Time Method Composite outcome of: 1. mortality in 30 days 30 days Cerebro-Vascular accidents 30 days Severe hypoglycemia 30 days Severe infections 30 days Severe infections will be defined as a hospitalization as a result of sepsis, pneumonia or soft tissue infection or other infection requiring intravenous antibiotic therapy that occurred during hospitalization.
Cardiac ischemic events 30 days
- Secondary Outcome Measures
Name Time Method Length of hospitalization 90 days Will be measured as the number of days from the admission to the discharge from hospital.
Repeat hospitalizations within 90 days 90 days Repeated hospitalizations will be defined as the number of repeated hospitalizations in 90 days.
Each component of the primary outcomes 30 days Severe infections within 90 days 90 days Severe infections will be defined as a hospitalization as a result of sepsis, pneumonia or soft tissue infection or other infection requiring intravenous antibiotic therapy that occurred during hospitalization.
Trial Locations
- Locations (2)
Rambam Medical Center
🇮🇱Haifa, Israel
Rabin Medical Center
🇮🇱Petah Tikva, Israel