The Efficacy of Long-term Whole-body Vibration in the Treatment of Parkinson's Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Unified Parkinson's Disease Rating Scale (UPDRS) section III
研究概览
简要总结
This study will evaluate whether whole-body vibration applied over a 12-week period is effective in treating motor symptoms of Parkinson's disease.
详细描述
Parkinson's disease (PD) is a progressive neurodegenerative disease resulting in the loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the striatum.
Whole-body vibration (WBV) is potentially beneficial in treating Parkinson's disease because it has been shown to elicit effects specific to both the brain and muscular system. Animal models of PD indicate that whole-body vibration can increase striatal dopamine levels, as well as the number of dopaminergic neurons in the substantia nigra. These findings were correlated with increased levels of brain-derived neurotrophic factor.
In addition to the potentially neuroplastic effects, >20 Hz WBV has been shown to improve muscular performance. Improved muscular performance is believed to be attributed to WBV induced neuromuscular effects rather than muscle hypertrophy, with the specific mechanism defined as the tonic vibration reflex.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with idiopathic Parkinson's Disease by a Neurologist
- •Currently taking anti-Parkinsonian medication
- •Able to stand for 2 minutes without assistance
- •Able to walk 10 meters without assistance
- •Ability to understand English instructions
- •Normal or corrected vision
排除标准
- •A neurological disease other than PD
- •recent stroke
- •cardiovascular disease
- •previous major hemorrhage
- •artificial pacemaker
- •currently pregnant
- •Current participation in any physical therapy or experimental treatments
- •Peripheral neuropathy, severe osteoporosis
- •Visual impairments that cannot be corrected
- •Clinically diagnosed with dementia
- •Greater than mild dementia (screened using Montreal Cognitive Assessment (MOCA) <24 being excluded)
结局指标
主要结局
Unified Parkinson's Disease Rating Scale (UPDRS) section III
时间窗: change from baseline, 12 weeks, and 2 week washout
clinician monitored motor evaluation
次要结局
- Timed Up & Go (TUG) Test(change from baseline, 12 weeks, and 2 week washout)
- Gait Assessment(change from baseline, 12 weeks, and 2 week washout)
- Timed Grooved Pegboard Task(change from baseline, 12 weeks, and 2 week washout)
研究者
Adam Koebel
Undergraduate Thesis Student
Sun Life Financial Movement Disorders Research and Rehabilitation Centre