Quantitative MR Biomarkers for Sarcoma Treatment
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Michigan
- Enrollment
- 11
- Locations
- 2
- Primary Endpoint
- To determine if MRI imaging can accurately determine if a sarcoma (tumor)is responding to the type of chemotherapy being used.
Study Overview
Brief Summary
To determine if MRI imaging can be used to accurately determine if a sarcoma is responding to the type of chemotherapy being used.
Detailed Description
The purpose of this study is to determine if MRI imaging can be used to accurately determine if a sarcoma is responding to the type of chemotherapy being used or if it is ineffective early on in the treatment; instead of finding this out 2-3 months later. If it is determined that MRI can accurately diagnose tumor response, medications can be switched early on potentially improv8ing the patients'chances of recovery.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Masking
- None
Eligibility Criteria
- Ages
- 3 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Biopsy proven primary bone or soft tissue tumor
- •No previous treatment for this malignancy
- •Will be given chemotherapy before having surgery or radiation on the tumor.
- •Are able to undergo a MRI examination
- •If your tumor measures at least 1/2 inch in length.
Exclusion Criteria
- •Younger than 3 yrs. of age or need general anesthesia(sedation that puts you to sleep) to have a MRI performed.
- •History of Renal Failure
- •Are not able to have a MRI performed for any reason such as you have a pacemaker or other implanted device that may malfunction or move because of the magnetic field inside the MRI room and scanner.
- •Have any history of an allergic reaction to gadolinium based contrast agents (a medication injected in a vein that helps create clearer MRI images.
Outcomes
Primary Outcomes
To determine if MRI imaging can accurately determine if a sarcoma (tumor)is responding to the type of chemotherapy being used.
Time Frame: Baseline prior to chemo
To image and evaluate the size of the soft tissue tumor prior to chemotherapy treatment.
Secondary Outcomes
- MRI Scan(3 weeks post start of chemo and end of chemo)
Investigators
Gary Luker M.D.
Principal Investigator
University of Michigan