The Effect of Methylphenidate on Motor Learning in Stroke Patients
- Conditions
- Cerebrovascular Accident
- Registration Number
- NCT00396058
- Lead Sponsor
- University of Aarhus
- Brief Summary
The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.
- Detailed Description
Stroke patients are to be examined with transcranial magnetic stimulation (TMS) before and after a short training session. TMS will be used to demonstrate changes in cortical excitability (motor threshold) and intracortical inhibition and facilitation. The effect of methylphenidate on baseline TMS measures will be evaluated as well as the effect on training induced changes in TMS measures (by comparing baseline and posttraining measures). The patients will be trained on two separate occasions, to compare the effect of Methylphenidate to placebo.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 13
- Less than two months after first stroke.
- Moderate to light hand paralysis
- Measurable MEP in the abductor pollicis brevis muscle
- Able to read and understand the written information
- Signed informed consent
- Epilepsy
- Glaucoma
- Hyperthyroidism
- Cardiac arrythmia
- Known heart disease or angina.
- Metal implants
- Pacemaker
- Pregnancy
- Diastolic BP>100 mmHg
- In treatment with MAO-inhibitor, SSRIs og Ritalin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Training induced changes in Short interval Intracortical Inhibition (SICI). Training induced changes in Intracortical facilitation (ICF)
- Secondary Outcome Measures
Name Time Method Baseline SICI, ICF, and motor threshold compared between methylphenidate and Placebo
Trial Locations
- Locations (2)
Hammel neurocenter
🇩🇰Hammel, Denmark
Department of neurology
🇩🇰Aarhus, Denmark