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临床试验/NCT04481178
NCT04481178Unknown不适用

A Retrospective Study on Laser Treatment of Nevus of Ota in Thai Patients

Mahidol University1 个研究点 分布在 1 个国家目标入组 79 人开始时间: 2020年9月15日最近更新:
适应症

试验速览

阶段
不适用
入组人数
79
试验地点
1
主要终点
Efficacy of laser treatment in paitients with Nevus of Ota

研究概览

简要总结

A retrospective study on efficacy and complication of laser treatment (Q-switched Nd:YAG and picosecond laser) of nevus of Ota in Thai patients

详细描述

Nevus of Ota is a benign dermal melanocytic nevus found most commonly in Asians. About 50-60% of all cases have the age of onset at birth or within the first year of life, others appear before puberty. It typically presents as a unilateral mottled blue-gray macules and patches distributed along the first and second branches of trigeminal nerve. Due to its marked hyperpigmentation on the face which does not resolved spontaneously, patients may experience psychosocial disturbances and often seek for treatments. Based on selective photothermolysis theory, Q-switched lasers (ruby 694nm, alexandrite 755nm, Nd:YAG 1064nm) have been used for the treatment of nevus of Ota with a success rate of 95% after 6-8 sessions. Reported complications from the lasers are hypopigmentation(15.3%), hyperpigmentation(2.9%), texture changes (2.9%), and scarring (1.9%). Siriraj Skin Laser Center provides laser treatment for nevus of Ota using mainly Q-switched Nd:YAG laser and Picosecond laser. The study of efficacy and complications of Q-switched Nd:YAG and Picosecond laser in the treatment of Nevus of Ota in Thai patients has never been reported. Therefore, we conduct a retrospective study on efficacy and complication of laser treatment (Q-switched Nd:YAG and picosecond laser) of nevus of Ota in Thai patients.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Patient with Nevus of Ota
  • Complete data between January 2008 - December 2018

排除标准

  • Incomplete data

结局指标

主要结局

Efficacy of laser treatment in paitients with Nevus of Ota

时间窗: 2008-2018

Fading of lesions after treatment by chart review

次要结局

  • Complication of laser such as hyperpigmentation, hypopigmentation, and scars(2008-2018)
  • Relapse rate after laser treatment(2008-2018)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Woraphong Manuskiatti, M.D.

Professor

Mahidol University

研究点 (1)

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