High Intensity Training in patients with rheumatoid arthritis
Completed
- Conditions
- Rheumatoid arthritis (RA)Musculoskeletal DiseasesSeropositive rheumatoid arthritis
- Registration Number
- ISRCTN62313758
- Lead Sponsor
- ALF Foundation (Sweden)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Twenty female patients after menopause
2. RA according to American College of Rheumatology criteria
3. Less than 12 months since diagnosis
4. Stable medication since at least three months
5. Independent in daily living
6. Passed menopause
7. Speak and understand Swedish
8. No other major disease that prevent them from performing intensive strength training
Exclusion Criteria
Does not comply with the above inclusion criteria.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Static and isokinetic muscle strength in knee extensors and knee flexors measured electronically with the Kin-Com.<br><br>Both the primary and the secondary outcomes will be measured at baseline and at three month follow up.
- Secondary Outcome Measures
Name Time Method 1. Clinical outcome (body functions, pain, fatigue and perceived health)<br>2. Inflammation<br>3. Pain mechanisms<br>4. Comorbidity<br>5. Muscle biopsies from vastus lateralis analysed for reactive oxygen species/reactive nitrogen species and expression of oestrogen receptors in muscles from patients with RA patients and controls before and after the intervention<br><br>Both the primary and the secondary outcomes will be measured at baseline and at three month follow up.