The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI) and cerebral perfusion regulatio
Completed
- Conditions
- Mild cognitive impairmentstarting memory problems10012272
- Registration Number
- NL-OMON42347
- Lead Sponsor
- Geriatrie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
Diagnosis of Mild cognitive impairment (MCI) (Peterson criteria or practical identification)
Physical ability sufficient to allow performance of endurance exercise training
Exclusion Criteria
Diagnosis of dementia/Alzheimer's disease
Engagement in moderate-intensity aerobic exercise training for more than 30 minutes, 3 times per week, during past 2 years
History of brain damage
History of myocardial infarction
Unstable chronical disease
Uncontrolled hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is cognitive performance, determined by a<br /><br>neuropsychological test battery. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes are physical fitness, cerebral autoregulation,<br /><br>cerebrovascular reactivity, prefrontal oxygenation, arterial stiffness,<br /><br>endothelial function, quality of life, epigenetics and cerebral structure</p><br>