Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia
- Conditions
- Ventilator Associated Pneumonia
- Interventions
- Drug: Placebo gel
- Registration Number
- NCT00597688
- Lead Sponsor
- All India Institute of Medical Sciences, New Delhi
- Brief Summary
The purpose of this study is to determine if oral mucosal application of chlorhexidine gel will prevent the development of ventilator associated pneumonia in children.
- Detailed Description
Ventilator associated pneumonia as the name suggests refers to pneumonia occurring in the setting of mechanical ventilation. It accounts of 86% of nosocomial pneumonia and in contrast to other more common nosocomial infections is accompanied by a mortality rate of upto 76% in certain settings. A number of preventive methods have been studied to reduce the rate of VAP but a consensus is lacking with regards to appropriate preventive strategies. Studies in adults have shown a beneficial effect of oral mucosal application of chlorhexidine but similar studies in pediatric population are not available. This research project aims at addressing the gap.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 86
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Chlorhexidine gel Chlorhexidine gel 2 Placebo gel Placebo gel
- Primary Outcome Measures
Name Time Method Occurrence of ventilator associated pneumonia as defined by CDC diagnostic criteria 21 days
- Secondary Outcome Measures
Name Time Method Antibiotic sensitivity of organism cultured 21 days Duration of hospital stay 21 days Duration of ICU stay 21 days In hospital mortality rate 21 days
Trial Locations
- Locations (1)
All India Institute of Medical Sciences
🇮🇳New Delhi, Delhi, India