Investigative cohort analysis of chronic airways disease in older adults with attention to asthma-COPD overlap syndrome: the Prospective Integrative Cohort of Chronic Airways Disease (PIRICA) study
Not Applicable
Recruiting
- Conditions
- Asthma, chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis
- Registration Number
- JPRN-UMIN000031185
- Lead Sponsor
- Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 1125
Inclusion Criteria
Not provided
Exclusion Criteria
1. Any kind of active respiratory infections including tuberculosis 2. Thoracic deformity which would influence pulmonary function tests 3. Any kind of malignant diseases in whom 3 year's follow-up would not be possible 4. History of lung resection 5. Any kind of pulmonary diseases including cystic fibrosis (CF), non-CF bronchiectasis, hypersensitivity pneumonitis, pulmonary fibrosis, secondary bronchiolitis obliterans, and others 6. Difficulty in performing pulmonary function tests due to dementia or other serious diseases 7. Deficient in alpha-1 antitrypsin 8. Judged to be inappropriate subjects for any reasons by principle investigators
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Moderate and severe exacerbation* free period and its frequency and annual change in FEV1 during the follow-up period based on clinical phenotypes of ACOS characterized by cluster analysis using clinical, physiological, and radiological parameters * Exacerbation will be defined as an acute event characterized by a worsening of the patient's respiratory symptoms (at least two of the symptoms of increased dyspnea, change in sputum purulence or increased sputum volume, increased cough, wheezing, or chest tightness) that is beyond day-to-day variations. Moderate exacerbation will be defined as new prescription of antibiotics and/or systemic corticosteroids due to exacerbation. Severe exacerbation will be defined as emergency room visit and/or admission due to exacerbation.
- Secondary Outcome Measures
Name Time Method