CTIS2023-506437-29-00招募中1 期
GLP-1 receptor agonists as preventive treatment of diabetes after renal transplantation: randomized clinical trial.Study 1: Immediate Kidney Transplant Recipients
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 128
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •De novo kidney transplant recipients older than 18 years,, No history of diabetes (by clinical history, verbal information from patients directly or with pre-transplant HbA1c = 6.5%),, Who receive tacrolimus and prednisone as maintenance immunosuppressive treatment in the post-transplant period, And with high risk of PTDM defined by two of these factors: -age > 50 years; -BMI = 30 kg/m2; -first degree family history of diabetes; -hypertriglyceridemia (triglyceride level >2.82 mmol/L); -prediabetes (defined by any of: fasting glucose 100–126 mg/dL (5.6–6.9 mmol/L), or HbA1c 5.7–6.4%, or if available oral glucose tolerance test prior to inclusion with values of initial glucose <126 mg/dL (7 mmol/L) and 2h after the load between 140–200 mg/dL (7.8–11 mmol/L)., Women of childbearing potential using effective contraception during study participation.
排除标准
- •Under 18 years of age,, previously diagnosed diabetes,, Hepatic failure, history of pancreatitis (acute or chronic),, multiple endocrine neoplasia syndrome type 2 (MEN 2),, personal or family history history of medullary thyroid carcinoma (MTC), pregnant or lactating women, moderate to severe pre-existing gastroparesis
研究者
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