Licorice and Home Blood Pressure, Additional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- Systolic home blood pressure
研究概览
简要总结
Out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. The aim of this study is to analyze the association between licorice intake and home blood pressure.
详细描述
For a detailed background, please see Clinical Trials registration number NCT05661721. In brief, out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. In a previous study, the response to licorice intake varied between participants. The aim of this study is to analyze the response of the most "licorice sensitive" quartile of participants from the original study to lower dosages of licorice, corresponding to 20 and 50 milligram och GA daily.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 31 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Previous participation in the Licorice and home blood pressure study (NCT05661721).
排除标准
- •Known hypertension, cardiovascular disease, kidney disease, liver disease, hormonal disease, peanut allergy, eating disorder or headache disease (including tension headache and migraine)
- •Known alcohol abuse or drug abuse (including cannabis and anabolic steroids) treatment with hormonal drugs (including oral contraceptives
- •Known intolerance to licorice intake.
结局指标
主要结局
Systolic home blood pressure
时间窗: 3 days before interventions and 28 days during intervention
Systolic home blood pressure
次要结局
- Diastolic home blood pressure(3 days before interventions and 28 days during intervention)
- Plasma N-terminal pro B-type natriuretic peptide(Day 0, 14 and 28)
- Body weight(Day 0, 14 and 28)
- Plasma potassium(Day 0, 14 and 28)
- Plasma sodium(Day 0, 14 and 28)
- Serum aldosterone(Day 0, 14 and 28)
- Plasma creatinine(Day 0, 14 and 28)
- Plasma renin(Day 0, 14 and 28)
研究者
Peder af Geijerstam
Principal investigator
Linkoeping University