A Comparison of Propofol-based Total Intravenous Anesthesia and Desflurane Anesthesia on NK cell Activity After Major Hepatic Resection in Hepatocellular Carcinoma Patients

Phase 2

Completed

• Conditions: on-metastatic hepatocellular carcinoma patients requiring major hepatectomy; Hepatocellular Carcinoma; NK cells activity; Anesthetic technique

• Registration Number: TCTR20210218001
• Lead Sponsor: Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-01-04
• Study Start: 2021-02-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

1.Patients diagnosed with non-metastatic HCC
2.Aged 18 to 75 years
3.ASA physical status I-III
4.Scheduled for elective major hepatic resection

Exclusion Criteria

1. Unsuccessful epidural catheter insertion for pain control
2. Patients refusal
3. Diagnosed with recurrent HCC before the research participation
4. Known allergy to medications used in the research protocol
5. Severe systemic diseases such as cardiovascular, respiratory, or endocrine system conditions
6. Frequent users of anxiolytics and opioids
7. Addiction to alcohol or drug abuse
8. Psychiatric conditions
9. Immunocompromised or receive immunosuppressive drugs within 6 months
10. Diagnosed with or family history of malignant hyperthermia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
K cell cytotoxicity 24 hour postoperatively laboratory results

Secondary Outcome Measures

Name	Time	Method
Interleukin-6 24 hour postoperatively laboratory results,Interleukin-10 24 hour postoperatively laboratory results,Recurrent rate 2 years postoperatively Whole abdominal CT scan