A Comparison of Propofol-based Total Intravenous Anesthesia and Desflurane Anesthesia on NK cell Activity After Major Hepatic Resection in Hepatocellular Carcinoma Patients

Not Applicable

• Conditions: Hepatocellular carcinomaAnesthetic agents suppress NK cell activityAnesthetic agents decline IL- 6, IL- 10 level; Nk cell activity; Anesthetic; 6; 10; Intravenous; Inhalation

• Registration Number: TCTR20190423003
• Lead Sponsor: Ratchadapiseksompotch Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-23
• Study Completion: 2022-06-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

HCC patients undergoing hepatectomy
ASA physical status 1-3
acceptable for epidural catheter insertion

Exclusion Criteria

Recurrent HCC patients
Severe systemic disease
Chronic opioid or sedative drug or alcohol uses
Refuse for participation
Immunocompromised patients
Immunosuppressive drug received patients
history of suspected malignant hyperthermia

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of NK cell activity at postoperative 24 hour flow cytometry

Secondary Outcome Measures

Name	Time	Method
Interleukin-6 at postoperative 24 hour ELISA,Interleukin 10 at postoperative 24 hour ELISA