A study comparing drugs such as lignocaine, dexmedetomidine, lignocaine-dexmedetomidine combination on changes of heart rate and mean blood pressure after skull pin application in head surgery patients

Not Applicable

Completed

• Conditions: Health Condition 1: O- Medical and Surgical

• Registration Number: CTRI/2022/07/043657
• Lead Sponsor: AIIMS Rishikesh

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 160

Inclusion Criteria

1] Patients aged 18-60 years

2] Either gender of ASA I-III patients

3] GCS 13 or more

4] Scheduled for excision and surgical decompression for elective Intracranial Space Occupying Lesions

Exclusion Criteria

1] Refusal to Consent

2] Patients with GCS <13

3] Patients with psychotic disorders and on medication or therapy

4] Patients with history of substance abuse/ chronic use of opioid analgesics

5] Known/suspected allergy to the study drugs

?Pregnant patients

?Patients with second and third degree Heart Block

?Patients with history of use of ?? blockers

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart Rate, Mean arterial pressureTimepoint: 1] Baseline values <br/ ><br>2] Before Induction of anaesthesia <br/ ><br>3] After induction of anaesthesia <br/ ><br>?Before skull pin insertion <br/ ><br>?On application of skull pin and every minute up to first 10 minutes. <br/ ><br>?And every 5 minutes for next 20 min. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Blood SugarTimepoint: 1) Baseline <br/ ><br>2) following induction of anaesthesia <br/ ><br>3) 30 minutes after skull pin insertion;Changes in Bispectral indexTimepoint: During skull pin insertion;Dose of propofol needed to achieve end point of induction of anaesthesiaTimepoint: After induction of anaesthesia;Intraoperative fentanyl requirementTimepoint: At the end of the surgery;Neutrophil-Lymphocyte ratioTimepoint: 1) Preoperative on the day of surgery <br/ ><br>2) 30 minutes after skull pin insertion;Serum CortisolTimepoint: 1) Preoperative on the day of surgery <br/ ><br>2) 30 minutes after skull pin insertion;Serum ProlactinTimepoint: 1) Preoperative on the day of surgery <br/ ><br>2) 30 minutes after skull pin insertion