Comparison of lignocaine and dexmedetomidine in suppressing of cough reflex and hemodynamic response during tracheal extubation after supratentorial tumour surgery: A Randomized control study
Phase 3
- Conditions
- Health Condition 1: C710- Malignant neoplasm of cerebrum, except lobes and ventricles
- Registration Number
- CTRI/2023/02/050064
- Lead Sponsor
- AIIMS Raipur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients diagnosed with supratentorial tumors planned for excision
2.ASA- I or II
3.Age between 18 - 65 years.
Exclusion Criteria
1.Use of angiotensin -converting enzyme inhibitors (ACE-I), beta blockers, digoxin, α2-agonist
2.Bradycardia (heart rate < 50/minute) or an atrioventricular conduction block
3.Arterial blood pressure < 90/60 mmHg
4.Renal and hepatic insufficiency
5.Local anesthetic allergy
6.Coagulation abnormalities
7.Patientâ??s refusal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of intravenous infusion of dexmedetomidine and lignocaine in attenuating cough reflex and hemodynamic response during tracheal extubation after supratentorial tumor surgery under general anesthesia.Timepoint: At the stoppage of anaesthetic gases to 15 min after extubation
- Secondary Outcome Measures
Name Time Method 1.Emergence time from general anesthesia <br/ ><br>2.Extubation time <br/ ><br>3.Consumption of intraoperative fentanyl <br/ ><br>4.Amount of intra-operative Norepinephrine use <br/ ><br>5.Modified Aldrete score (Post anesthesia care unit discharge criteria) <br/ ><br>6.Time to first analgesia <br/ ><br> <br/ ><br> <br/ ><br>Timepoint: At the stoppage of anaesthetic gases to 15 min after extubation