Effect of Anesthesia technique on anti tumor immunity as seen by TNF-B levels in adult patients undergoing surgery for oral cancer
Not Applicable
Completed
- Conditions
- Health Condition 1: C10- Malignant neoplasm of oropharynx
- Registration Number
- CTRI/2022/03/040751
- Lead Sponsor
- Department of OncoAnesthesia and Palliative Medicine DR BRAIRCH AIIMS New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
1) Patients undergoing surgery for Oral cancer
2) American Society of Anesthesiologists
classification of Physical Health GRADE I, II,
III.
Exclusion Criteria
1.Patient refusal.
2.Allergy to any of the study drugs.
3.Chronic kidney and liver disease.
4.Blood transfusion in perioperative period.(30
days prior to surgery and Up to 24 hrs
postoperative period)
5.Atrioventricular conduction disorders.(Either
with pacemaker or on antiarrhythmics)
6.Heart failure on treatment with beta blockers.
7.Patients with chronic pain preoperatively
already receiving Opioids.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To detect the difference in the Post-operative Serum TGF-ß levels in patients receiving lignocaine infusion and dexmedetomidine infusion based anaesthesia in patients of Oral Cancer undergoing surgery.Timepoint: 24 hrs after surgery in postoperative period
- Secondary Outcome Measures
Name Time Method To compare incidence of peri-operative complications (pruritus, nausea, vomiting, bradycardia, hypotension) among the study groups.Timepoint: 24 hrs after surgery in postoperative period;To compare the total opioid consumption in perioperative period among the study groups.Timepoint: 24 hrs after surgery in postoperative period;To detect the difference in perioperative systemic inflammation and anti-tumour immunity: change between preoperative and postoperative T-helper cell profile, IL-6, Neutrophil Lymphocyte ratio (NLR), Platelet Lymphocyte ratio (PLR), Monocyte Lymphocyte Ratio (MLR) and modified Glasgow Prognostic Score (m GPS).Timepoint: 24 hrs after surgery in postoperative period