Vitamin D levels in adults with non-atopic asthma: a case-control study

Completed

Conditions: asthma
bronchitis
10006436

Registration Number: NL-OMON34269

Lead Sponsor: Medisch Centrum Leeuwarden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 216

Inclusion Criteria

Group 1:
- Outpatients with non-atopic asthma, determined by negative alatop
- Age * 18 yrs
- Pulmonologist*s diagnosis of asthma
- Documented reversibility in FEV1 of > 12% predicted OR airway hyperresponsiveness to inhaled methacholine
Group 2:
- Outpatients with atopic asthma, determined by known positive alatop or skin prick test
- Age * 18 yrs
- Pulmonologist*s diagnosis of asthma
- Documented reversibility in FEV1 of > 12% predicted OR airway hyperresponsiveness to inhaled methacholine
Group 3:
- Subjects without pulmonary history or pulmonary complaints
- Age * 18 yrs
- No signs of allergy and negative alatop
- Normal spirometry

Exclusion Criteria

Group 1:
- Patients with smoking history of > 10 packyears and persistent airflow obstruction (post bronchodilator FEV1 < 80%pred): excluded if reversibility in FEV1 < 12% predicted OR TLCO < 80%pred
- Pregnancy
- Use of supplements containing vitamin D analogues in the last 6 months
- Other pulmonary diseases
Group 2:
- Patients with smoking history of > 10 packyears and persistent airflow obstruction (post bronchodilator FEV1 < 80%pred): excluded if reversibility in FEV1 < 12% predicted OR TLCO < 80%pred.
- Pregnancy
- Use of supplements containing vitamin D analogues in the last 6 months
- Other pulmonary diseases
Group 3:
- Pulmonary history or current pulmonary complaints
- Use of supplements containing vitamin D analogues in the last 6 months
- Pregnancy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference between vitamin D levels of patients with non-atopic asthma and<br /><br>and patients with atopic asthma and the difference between vitamin D levels of<br /><br>patients with non-atopic asthmaand healthy non-atopic subjects .</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>virus serology<br /><br>Genetic tests<br /><br><br /><br>Pulmonary function testing: spirometry<br /><br>ACQ (asthmatic patients)<br /><br>Medical consumption (asthmatic patients)<br /><br>Time spent outdoors</p><br>