Effects of levosimendan on diaphragm contractility in healthy subjects
Completed
- Conditions
- respiratory muscle weakness and fatigueweaning1002931710028302
- Registration Number
- NL-OMON35071
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
- age > 18 year
- informed consent
Exclusion Criteria
- use of any prescript medication
- chronic hiccups (defined as hiccups longer than 15 minutes in the past 6 months)
- pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including diabetes and auto-immune diseases.
- pre-existent lung disease
- pre-existent cardiac disease- pregnancy, breast feeding
- innability to obtain adequate view of the heart with transthoracic echocardiography
- upper airway / esophageal pathology
- recent (< 1 month) nasal bleeding
- phrenic nerve lesions
- any metals in body (pacemaker, splinters, metal stiches)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the transdiaphragmatic pressure, diaphragm<br /><br>efficiency, maximal inspiratory pressure and tenson time index before and after<br /><br>levosimendan infusion.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>