The Effect of Methyl-Sulphonyl-Methane on Osteoarthritis and Joint Cartilage Associated With the Degeneration of the Chondrocyte
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Number of participants with improved Mobility
研究概览
简要总结
To delineate the effect of MSM on osteoarthritis
详细描述
Objective
To delineate the effect of MSM on osteoarthritis of large joints. Design: Randomized, double-blind, placebo-controlled trial including an intervention and a placebo group. One hundred men and women, with hip and/or knee OA to be divided in 2 groups. Intervention is either MSM 3 gr twice a day for 26 weeks (6 gr/day total) for one group and placebo for the other. Outcomes measured are the Western Ontario and McMaster University Osteoarthritis Index visual analogue scale (WOMAC), patient and physician assessments and SF-36 (overall health-related quality of life).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Knee and hip OA
- •men and women >45 years of age
排除标准
- •any other type of arthritis
- •chronic pain syndrome
- •arthroscopic surgery in the past 8 months
- •intra-articular corticosteroidsin the past 8 months
- •hyaluronic acid injections in the past 8 months
- •narcotic pain killers use
- •renal or hepatic disease
- •body mass index (BMI) >45 kg/m2
研究组 & 干预措施
MSM group
Intervention is MSM 3 gr twice a day for 26 weeks (6 gr/day total)
干预措施: MethylSulfonylMethane (MSM) (Drug)
Placebo Group
Placebo 3 gr twice a day for 26 weeks (6 gr/day total)
干预措施: Placebo (Drug)
结局指标
主要结局
Number of participants with improved Mobility
时间窗: 26 weeks
Randomized, double-blind, placebo-controlled trial including an intervention and a placebo group. One hundred men and women, with hip and/or knee OA were divided in 2 groups. Intervention was either MSM 3 gr twice a day for 26 weeks (6 gr/day total) for one group and placebo for the other. Outcomes measured were the Western Ontario and McMaster University Osteoarthritis Index visual analogue scale (WOMAC)
次要结局
- Pain Scores on the Visual Analog Scale(26 weeks)
研究者
Thomas Pagonis
Orthopaedic Surgeon
G.Papanikolaou Research Group