The effect of administering high doses of intravenous vitamin C in severe traumatic brain injuries
Phase 3
Recruiting
- Conditions
- severe traumatic brain injuries.Multiple injuries of headS09.7
- Registration Number
- IRCT20230530058344N1
- Lead Sponsor
- Qazvin University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 69
Inclusion Criteria
Patient age 18 to 60 years
Patients with severe brain damage (GCS = 8)
Patients who have not undergone surgery
Informed consent of the first degree relatives of the patients and completion of the consent form
Exclusion Criteria
Chronic Kidney Disease
End-Stage Renal Disease (ESRD)
Pregnancy and breastfeeding
Hemochromatosis patients
Reluctance to cooperateIn the study
Chronic liver diseases (cirrhosis, hepatitis, etc.)
History of kidney stones
Vitamin C allergy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in the patient's clinical status and consciousness based on the GCS scale. Timepoint: At the time of entering the ICU, the second day, the fourth day and during transfer to the ward. Method of measurement: Glasgow Coma Scale.
- Secondary Outcome Measures
Name Time Method The duration of the patient's stay in the ICU and the hospital. Timepoint: When discharged from the hospital. Method of measurement: Counting days of hospitalization.;8 and 28 day mortality rate. Timepoint: 8 and 28 days after ICU admission. Method of measurement: Counting days of hospitalization.