Effect of High Doses of intravenous Vitamin C on Coagulation Factors and Vascular endothelium in Sepsis Patients.

Phase 3

• Conditions: Covid 19.; Coronavirus infection, unspecified; B34.2

• Registration Number: IRCT20190718044264N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Having sepsis according to the criteria stated in the surviving sepsis campaign 2016 Guideline based on SOFAScore

Exclusion Criteria

Age less than 18 years
Age above 80 years
pregnancy
Suffering from kidney failure: AKI according to the definition of KDIGO guidelines
Receiving other antioxidants 24 hours before and during the study (NAC, melatonin and selenium)
Receive intravenous fibrinogen
Receive intravenous PCC
Receiving heparin with a therapeutic dose
INR?1.5
(PLT?100000 ) Thrombocytopenia
Patients receiving warfarin
Hemochromatosis patients
Chronic renal failure (GFR?40)
More than 48 hours have passed since the onset of sepsis

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Antithromobin III. Timepoint: From the beginning to the end of the course. Method of measurement: elisa kit.;Neutrophil to lymphocyte ratio. Timepoint: From the beginning to the end of the course. Method of measurement: Counting blood cells (CBC diff).;Syndecan-1. Timepoint: From the beginning to the end of the course. Method of measurement: Kit.;Mortality. Timepoint: From the beginning to the end of the course. Method of measurement: observation.;Vasopressor dose. Timepoint: From the beginning to the end of the course. Method of measurement: observation.;CRP/ALB ratio. Timepoint: From the beginning to the end of the course. Method of measurement: Laboratory.;ACR. Timepoint: From the beginning to the end of the course. Method of measurement: Laboratory.;FDP/D-Dimer Ratio. Timepoint: From the beginning to the end of the course. Method of measurement: Laboratory.