A Randomized-controlled Trial of a Targeted Approach to Fluid Resuscitation in Acute Pancreatitis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Acute Pancreatitis
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Prevalence (point prevalence) of the systemic inflammatory response syndrome (SIRS) at 24 hours
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
Vigorous fluid resuscitation is currently believed to play a key role in reducing complications associated with acute pancreatitis. However, aggressive fluid replacement can be associated with complications such as pulmonary fluid sequestration. The purpose of this study is to evaluate alternative approaches to early fluid resuscitation for patients with acute pancreatitis.
Detailed Description
Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis. Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal saline on systemic inflammation in acute pancreatitis.
Investigators
Bechien Wu, MD, MPH
Bechien Wu, M.D., M.P.H.
Brigham and Women's Hospital
Eligibility Criteria
Inclusion Criteria
- •acute pancreatitis diagnosed by at least 2 criteria
- •adult patients at least 18 years of age
Exclusion Criteria
- •history of severe cardiovascular, respiratory, renal, hepatic or hematologic/immunologic disease
- •concurrent metabolic or physiologic derangement requiring specific fluid management
- •pregnancy
- •patients transferred from acute care hospital
Outcomes
Primary Outcomes
Prevalence (point prevalence) of the systemic inflammatory response syndrome (SIRS) at 24 hours
Time Frame: first 24 hours of hospitalization