Fluid Lavage of Open Wounds (FLOW): a multicentre, blinded, factorial trial comparing alternative irrigating solutions and pressures in patients with open fractures

McMaster University (Canada)0 个研究点目标入组 2,280 人开始时间: 2009年7月13日最近更新: 2019年5月5日

适应症

试验速览

•1. Open fractures with an associated vascular deficit (Gustilo-Anderson Type IIIC)
•2. Known allergy to detergents or castile soap ingredients
•3. Previous wound infection or history of osteomyelitis in the injured extremity
•4. Previous fracture with retained hardware in injured extremity that will interfere with new implant fixation
•5. Surgical delay to operative wound management greater than 24 hours from hospital admission
•6. Use of immunosuppressive medication within 6 months
•7. Immunological deficient disease conditions (e.g., human immunodeficiency virus [HIV])
•8. Fracture of the hand (metacarpals and phalanges)
•9. Fracture of the toes (phalanges)
•10. Likely problems, in the judgment of the investigators, with maintaining follow-up. We will, for example, exclude patients with no fixed address, those who report a plan to move out of town in the next year, or intellectually challenged patients without adequate family support.
•11. Previous randomisation in this study or a competing study
•12. Patient is a prisoner or is at high risk of incarceration during the follow-up period

发起方

McMaster University (Canada)