Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease

Not Applicable

Completed

• Conditions: Alzheimer's Disease
• Interventions: Dietary Supplement: 1-month of 60-40 MCT oil; Dietary Supplement: 1-month of C8 MCT oil

• Registration Number: NCT02709356
• Lead Sponsor: Université de Sherbrooke

Brief Summary

Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.

Detailed Description

Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2016-02-01
• Study First Submitted QC: 2016-03-10
• Study First Posted: 2016-03-16
• Status Verified: 2017-12
• Primary Completion: 2018-02
• Study Completion: 2018-02
• Last Update Submitted: 2018-10-09
• Last Update Posted: 2018-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Good general health for Control group
• Diagnosis of Alzheimer's disease (NINCDS-ADRDA criteria) for AD group

Exclusion Criteria

• Depression
• Medical or psychiatric conditions that could interfere with study participation
• Fasting plasma glucose ≥7.0 mM (diabetes or prediabetes)
• Already on MCT supplementation
• Clinically-significant gastrointestinal disease/conditions
• Clinically-significant liver disease/dysfunction
• Clinically-significant renal disease/dysfunction
• Clinically-significant cardiac disease/conditions
• Hypertension
• Uncontrolled dyslipidaemia
• Vitamin B12 deficiency
• Structured physical activity (more than 3 times/week)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Alzheimer's disease	1-month of C8 MCT oil	Patients with mild Alzheimer's disease. 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)
Controls	1-month of C8 MCT oil	Healthy elderly people 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)
Controls	1-month of 60-40 MCT oil	Healthy elderly people 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)
Alzheimer's disease	1-month of 60-40 MCT oil	Patients with mild Alzheimer's disease. 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)

Primary Outcome Measures

Name	Time	Method
Quantification of brain glucose uptake	1-month	Brain glucose uptake (umol/100g/min) using 18-FDG PET scan
Quantification of brain acetoacetate uptake	1-month	Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET scan

Trial Locations

Locations (1)

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS); 🇨🇦 Sherbrooke, Quebec, Canada