Effects of Acute Stress Exposure on Plasma Beta-amyloid Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Plasma amyloid-beta-42
研究概览
简要总结
Research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for Alzheimer's disease. Some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain Alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. However, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels in humans has yet to be examined.
In this study, the investigators will examine whether brief increases in sympathetic activation result in immediate changes in plasma amyloid-beta levels in the five hours after exposure.
详细描述
Aim 1: determine whether acute exposure to stress (increasing sympathetic nervous system activation) increases plasma amyloid-beta-40 and amyloid-beta-42 in the five hours following exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult weighing at least 110 pounds
- •No chronic conditions or illness
- •Taking no medications or drugs that might alter the stress response (e.g., corticosteroids, beta-blockers, and others)
- •Not using any hormone-containing medication (e.g., hormonal contraceptives, hormone replacement, etc.)
- •No contraindications for cold pressor test exposure (high blood pressure, heart disease, dysrhythmia, peripheral vascular disease, any other cardiovascular disorder, diabetes, vasculitis, lupus, tingling or numbness in the hands and/or feet, cryoglobulinemia, and Reynaud's phenomenon)
- •No history of fainting during blood draws
- •No phobia of having their blood drawn
- •No general history of fainting or seizures
- •Not currently diagnosed with a mood disorder (e.g., major depressive disorder)
- •Not pregnant in the past 12 months
- •Not lactating in the past 12 months
- •Not trying to become pregnant if premenopausal
- •Experienced natural menopause if postmenopausal
- •Be non-smokers
- •Be fluent in English
排除标准
- •- Unwilling to be filmed during the stress task OR unwilling to sign the waiver allowing their filmed responses to be used in scientific presentations
结局指标
主要结局
Plasma amyloid-beta-42
时间窗: 9.5 hours
Changes in levels of amyloid-beta-42 in blood from before to after acute intervention (stress/no-stress).
Plasma amyloid-beta-40
时间窗: 9.5 hours
Changes in levels of amyloid-beta-40 in blood from before to after acute intervention (stress/no-stress).
次要结局
未报告次要终点
研究者
Mara Mather
Professor of Gerontology, Psychology, and Biomedical Engineering
University of Southern California