Comparasion of two different doses of methylprednisolone with dexamethasone in patients with severe COVID 19 patients .

Phase 4

Not yet recruiting

• Conditions: Coronavirus as the cause of diseases classified elsewhere,

• Registration Number: CTRI/2021/11/038317
• Lead Sponsor: Government medical college

Brief Summary

We compare the effect of two different doses of methylprednisolone with standard dose of Dexamethasone in patients with severe covid 19 illness

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-12
• Last Update Posted: 2021-11-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 291

Inclusion Criteria

• Age 18-75 yrs 2.
• Adult patients with RTPCR confirmed.
• Patients with CT Scan features ( CORAD score4 and above) 4.
• Patients with severe COVID 19 infection whose room air saturation is <93% .

Exclusion Criteria

• Patients with multi organ failure , Shock , DIC .
• Patients with complicated COVID 19 infection .
• Respiratory failure due to other causes such as head injury , CNS infection , DKA, severe electrolyte disturbances, neuromuscular diseases .
• Past history of COPD , bronchial asthma .
• Patients with cardiac disease .
• Patients with chronic kidney disease on hemodialysis .

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality at day 14 and 28	Mortality at day 14 and 28 | No.of patients requiring invasive ventilation | No. Of icu days and hospital | Incidence of secondary infection
No.of patients requiring invasive ventilation	Mortality at day 14 and 28 | No.of patients requiring invasive ventilation | No. Of icu days and hospital | Incidence of secondary infection
No. Of icu days and hospital	Mortality at day 14 and 28 | No.of patients requiring invasive ventilation | No. Of icu days and hospital | Incidence of secondary infection
Incidence of secondary infection	Mortality at day 14 and 28 | No.of patients requiring invasive ventilation | No. Of icu days and hospital | Incidence of secondary infection

Secondary Outcome Measures

Name	Time	Method
Duration of hospital stay	Lower death rate

Trial Locations

Locations (1)

Bangalore Medical College and Research Institute; 🇮🇳 Bangalore, KARNATAKA, India

Bangalore Medical College and Research Institute

🇮🇳Bangalore, KARNATAKA, India

Dr Praveena R

Principal investigator

9110248311

Praveenar03@gmail.com