Intestinal Biomarker Analysis After ECP for ICI Colitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- T cell number and phenotype measurement in the intestinal tract
研究概览
简要总结
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the chnages of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
详细描述
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the changes of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICI colitis
排除标准
- •no informed consent
结局指标
主要结局
T cell number and phenotype measurement in the intestinal tract
时间窗: 6 months
Analysis of CD3+ T cells by flow cytometry
次要结局
- T cell number measurement by immunohistochemistry(6 months)
- Analysis of arginase amounts in the intestinal tract using qPCR(6 months)
研究者
Robert Zeiser
Director Division of Tumor immunology
University of Freiburg