The effect of combination therapy with anti-hypertensive drugs on central blood pressure
Not Applicable
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000007395
- Lead Sponsor
- Clinic Jingumae
- Brief Summary
Treatment with olmesartan/azelnidipine for 2 years resulted in greater improvements in central blood pressure, left ventricular mass index, left ventricular diastolic function, and arterial stiffness compared with olmesartan/amlodipine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1) secondary hypertension 2) arrhythmia 3) current treatmentfor congestive heart failure 4) a history of stroke or coronary artery disease 5) clinically significant valvular heart disease 6) renal insufficiency (serum creatinine >=2mg/dL) 7) mental disorders severe noncardiovascular disease 8) chronic inflammatory disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Central Blood Pressure Echocardiography
- Secondary Outcome Measures
Name Time Method Augmentation Index Brachial-Ankle Pulse Wave Velocity