ew optical techniques in interstitial lung disease

Recruiting

Conditions: Diffuse Parenchymal Lung disease
Interstitial lung disease
10024967

Registration Number: NL-OMON55811

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

Interstitial lung disease patients with an indication for lung tissue sampling

Exclusion Criteria

* Inability and willingness to provide informed consent
* Inability to comply with study protocol
* Use of clopidogrel, or other new anti-platelet therapy, or anticoagulant
drugs that cannot be stopped temporarily
* Thrombocytopenia < 70x10^9
INR > 1.3
* Pregnancy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-To describe visual qualitative characteristics of CLE, OCT and HHGM images of<br /><br>the alveolar compartment and the airway wall in ILD<br /><br>-To obtain quantitative measurements of ILD by analysis of the CLE, OCT and<br /><br>HHGM imaging of the alveolar compartment (size of the alveoli (um), thickness<br /><br>of the alveolar septum)<br /><br>-To compare the CLE, OCT and HHGM images with pathology results<br /><br>-To identify specific structures and cells (i.e. collagen fibres, elastin,<br /><br>inflammatory cells) on HHGM images of lung tissue<br /><br>-To identify specific structures and cells (i.e. collagen fibres, elastin,<br /><br>inflammatory cells) on HHGM images in ILD</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-To create an image atlas with pOCT, pCLE and HHGM images of the airway wall<br /><br>and alveolar compartment in ILD<br /><br>-Assessing procedure-related adverse events of pCLE and pOCT<br /><br>-Assessing technical feasibility of pCLE, pOCT and HHGM<br /><br>-To assess the timeframe that is necessary for adequate HHGM images of lung<br /><br>tissue in ILD</p><br>