Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
- Conditions
- Posttraumatic OsteoarthritisAnterior Cruciate Ligament (ACL) Rupture
- Registration Number
- NCT07142369
- Lead Sponsor
- Rush University Medical Center
- Brief Summary
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
- Detailed Description
The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 99
- Age 18 - 50
- English-speaking
- Clinical evidence of ACL rupture with swelling
- Participant must be undergoing ACL reconstruction surgery
- Age <18 or >50
- Presentation >3 weeks after initial injury
- Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
- > Kellgren-Lawrence grade 2 changes on preoperative x-ray
- History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Concentration of Collagen Type II Cytokine Enrollment up to surgery Breakdown cytokine found in damaged cartilage
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Rush University Medical Center🇺🇸Chicago, Illinois, United States