ong term vascular and psychosocial complications in adolescent and young adult survivors of head and neck cancer treated with radiotherapy.
Completed
- Conditions
- Vascular toxicity100822061002765610007963
- Registration Number
- NL-OMON48049
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
- Patients treated with unilateral radiotherapy of the neck at adolescent or
young adult age (18-40 year) 5-10 years before.
- Competent to make own discicions
- *18 years of age
Exclusion Criteria
- Contra indication MRI
- Not able to understand the Dutch language
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Vascular complications:<br /><br><br /><br>a. Intima Media thickness on ultrasonography in the irradiated versus the<br /><br>non-irradiated artery<br /><br>b. Carotid wall elastography on ultrasonography in the irradiated versus the<br /><br>non-irradiated artery<br /><br>c. Carotid wall thickness on MRI in the irradiated versus the non-irradiated<br /><br>artery<br /><br>d. Radiological characteristics of carotid wall changes on MRI of the<br /><br>irradiated versus the non-irradiated artery<br /><br>e. Cerebral infarctions and white matter lesions on MRI<br /><br>f. Cardiovascular risk profile 5-10 years after radiotherapy because of HNC</p><br>
- Secondary Outcome Measures
Name Time Method <p>2. Psychosocial complications:<br /><br><br /><br>a. Cognitive function 5-10 years after RT in HNC patients<br /><br>b. Frequency of memory complaints, anxciety, depression, fatique<br /><br>c. Employment ability</p><br>