D-mannose to prevent recurrent urinary tract infections: a double-blind randomised placebo-controlled study

niversity of Oxford0 个研究点目标入组 598 人开始时间: 2019年1月22日最近更新: 2024年5月13日

试验速览

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33441350/ protocol (added 15/01/2021) 2024 Results article in https://doi.org/10.1001/jamainternmed.2024.0264 (added 09/04/2024)

•1. Participant is willing and able to give informed consent for participation in the study
•2. Participant is able to comply with study procedures
•3. Female, aged 18 years or above
•4. Presented to ambulatory care with symptoms consistent with UTI three or more times in the last year or two or more times in the last six months

•1. Female participant who is pregnant, lactating or planning pregnancy during the course of the study
•2. Formal diagnosis of interstitial cystitis or overactive bladder syndrome
•3. Prophylactic antibiotics started in the last 3 months and unwilling to discontinue, or intention to start during the next 6 months
•4. Currently using D-mannose and unwilling to discontinue for the duration of the study
•5. Nursing home resident. Residential home residents will not be excluded
•6. Catheterised, including intermittent self-catheterisation
•7. Use of Uromune (an ‘immunostimulant’)
•8. Participants who have participated in a research study involving an investigational product in the past twelve weeks
•9. Previous participation in this study

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