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临床试验/NCT07528378
NCT07528378尚未招募不适用

Manipulating Social Percepts With Real-Time fMRI

Trustees of Dartmouth College0 个研究点目标入组 10 人开始时间: 2026年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
10
主要终点
Likelihood of certain social percepts (behavioral)

研究概览

简要总结

This study will investigate the use of real-time fMRI to change how participants perceive social information.

详细描述

The investigators have previously established stable individual differences in how people accumulate evidence for the presence and nature of a social interaction in visual displays, termed "social tuning curves". Taking individuals with deeply characterized neural and behavioral social tuning curves, this protocol will covertly manipulate percepts in two ways using real-time fMRI: 1) brain-state-triggered trials to bias participants toward a given percept based on their pre-stimulus brain state, and 2) implicit neurofeedback prior to and during stimulus exposure to teach participants to control their brain activity in social-perceptual circuits. These experiments will directly test causal relationships between activity at different levels of the cortical hierarchy and an individual's ultimate percept of a given social stimulus.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • willingness and availability to come for a total of 6 MRI scan sessions
  • good fMRI data quality in previous, non-clinical trial study, including low head motion, high vigilance during the task as measured via simultaneous eye tracking, consistent behavioral responses

排除标准

  • metallic objects in body contraindicated for the MRI scanner
  • history of severe psychiatric or neurological disease
  • currently on medication for a psychiatric condition
  • illicit drug use
  • claustrophobia
  • heavy nicotine or alcohol use
  • prior head injury
  • pregnancy

结局指标

主要结局

Likelihood of certain social percepts (behavioral)

时间窗: during fMRI session

Likelihood of participants to report perceiving certain types of interactions in social animations. Percepts are characterized according to if a social interaction was perceived, and if so, how it was perceived (on a valence axis from positive to neutral to negative).

次要结局

  • Control over brain activity (fMRI-based)(during fMRI session)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Emily S. Finn

Assistant Professor

Trustees of Dartmouth College

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