D-serine and Cognitive Remediation in Schizophrenia
- Registration Number
- NCT02156908
- Lead Sponsor
- Nathan Kline Institute for Psychiatric Research
- Brief Summary
The investigators will test the effects of 3 days of D-serine (DSR) on auditory plasticity in a sensory based remediation (SBR) paradigm
- Detailed Description
We will enroll 8 subjects in an open label, three session pilot in patients will receive three sessions of tone matching SBR.
5 Subjects will receive D-serine (60mg/kg) taken 1x each week during the SBR sessions. Subjects will receive study drug 30 minutes prior to session.
3 subjects received no intervention
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description D-serine D-serine D-serine
- Primary Outcome Measures
Name Time Method Mismatch Negativity (MMN) 3 weeks An MMN event is evoked by a discernible change in the pitch of a repetitive auditory stimulation. The stronger the response to a difference (i.e., the more negative the amplitude of the MMN), the better the outcome.
MMN was obtained to pitch deviant stimuli pre-post auditory plasticity training, utilizing deviants to the same base frequencies as the auditory plasticity sessions, (i.e. 500, 1000, and 2000 Hz), with \~10 minutes of each base frequency. MMN will be conducted at baseline and after the final session. Reported outcome is change in MMN between baseline and final within session.
- Secondary Outcome Measures
Name Time Method Tone Matching Threshold three weeks Change tone matching threshold (the percent difference in pitch of two consecutively played tones that can be distinguished), higher numbers represent better outcomes. D-serine outcomes are for 2 consecutive D-serine sessions
Trial Locations
- Locations (1)
Nathan Kline Institute
🇺🇸Orangeburg, New York, United States