Fetal heart rate variability in growth-restricted fetuses. Substudy of NTR 7132 'Fetal myocardial deformation throughout pregnancy'.
Recruiting
- Conditions
- Pregnancy, Fetal heart rate variability, Fetal growth restriction
- Registration Number
- NL-OMON27824
- Lead Sponsor
- Maxima Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Singleton pregnancy
-Age >18 years
Exclusion Criteria
-Multiple pregnancies
-Age <18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - To determine if there a significant differences in fetal heart rate variability between fetuses with FGR and healthy fetuses measured with the non-invasive fetal electrocardiogram and matched for gestational age.<br /><br>- To explore the process of fHRV parameters changing during gestation in fetuses with fetal growth restrictedtardation.<br /><br>- To determine if there is a relation between STE values and fHRV parameters in growth-retarded fetuses. <br><br>
- Secondary Outcome Measures
Name Time Method - We want to explore the feasibility to extract electrocardiographic waveforms from measurements done with the NI-fECG technique. These include beat-to-beat variations (RR-interval), PR interval, QRS interval, QT interval and ST segment. We will correlate this information to clinical parameters, such as neonatal outcome (pH, Apgar score) and several maternal parameters (BMI, analgesia during labour, gestational age, use of medication, maternal health status). Moreover, if possible in this dataset, we aim to provide reference values of the durations of the various waveform details. <br>