Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital Cardiac Arrest

Completed

• Conditions: Cardiac Arrest

• Registration Number: NCT04211207
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

It has been shown that elevation of the heart's respiratory quotient after cardiac surgery is predictive of the complications occurrence. In addition, a high heart's respiratory quotient is predictive of anaerobic metabolism after cardiac surgery. In the wake of cardiorespiratory arrest, the presence of anaerobic metabolism reflected by hyperlactatemia is an important prognostic factor. However, this monitoring is invasive and discontinuous. The hypothesis of the study is to show that a rise in the respiratory quotient by a non-invasive monitoring is a factor of poor prognosis in the wake of a Cardiac Arrest.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-12-17
• Study First Submitted QC: 2019-12-20
• Study First Posted: 2019-12-26
• Study Start: 2020-01-27
• Status Verified: 2022-11
• Primary Completion: 2023-07-31
• Study Completion: 2023-09-22
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Adult >18 years
• Admission to intensive care unit after a non-hospital cardiopulmonary arrest.
• Resumption of spontaneous cardiac activity.
• Non-opposition of the patient or his relatives

Exclusion Criteria

• Pregnancy
• Prior neurological impairment
• Persons deprived of their liberty by a judicial proceeding, or administrative decision.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart's respiratory value at H6 post intensive care unit admission to predict mortality	At 6 hours post intensive care unit admission	Physiological parameter

Secondary Outcome Measures

Name	Time	Method
Heart's respiratory value at H12 post intensive care unit admission to predict mortality	At 12 hours post intensive care unit admission	Physiological parameter
Heart's respiratory value at H6 post intensive care unit admission to predict neurological prognosis	At 6 hours post intensive care unit admission	Physiological parameter
Heart's respiratory value at H12 post intensive care unit admission to predict neurological prognosis	At 12 hours post intensive care unit admission	Physiological parameter
metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H6 post intensive care unit admission	At 6 hours post intensive care unit admission	Metabolic parameters
Heart's respiratory value at intensive care unit admission to predict neurological prognosis	At admission of intensive care unit	Physiological parameter
Heart's respiratory value at H24 post intensive care unit admission to predict neurological prognosis	At 24 hours post intensive care unit admission	Physiological parameter
metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at intensive care unit admission	At admission of intensive care unit	Metabolic parameters
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H6 post intensive care unit admission	At 6 hours post intensive care unit admission	Metabolic parameters
Heart's respiratory value at intensive care unit admission to predict mortality	At admission of intensive care unit	Physiological parameter
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H12 post intensive care unit admission	At 12 hours post intensive care unit admission	Metabolic parameters
Cardiac arrest circumstances following Utstein-style guidelines according mortality	At admission of intensive care unit	Metabolic parameters
Cardiac arrest circumstances following Utstein-style guidelines according neurological prognosis	At admission of intensive care unit	Cardiac arrest circumstances
Cerebral performance category (CPC) score at day 90	At 90 Days post intensive car unit admission	Cerebral performance category (CPC) score : CPC=1 : Conscious, alert, and oriented with normal cognitive functions, CPC=2 : Conscious and alert with moderate cerebral disability; CPC=3: Conscious with severe disability; CPC=4: Comatose or in persistent vegetative state; CPC=5 : Certified brain death or dead by traditional criteria.
Heart's respiratory value at H24 post intensive care unit admission to predict mortality	At 24 hours post intensive care unit admission	Physiological parameter
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H12 post intensive care unit admission	At 12 hours post intensive care unit admission	Metabolic parameters
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H24 post intensive care unit admission	At 24 hours post intensive care unit admission	Metabolic parameters
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at intensive care unit admission	At admission of intensive care unit	Metabolic parameters
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H24 post intensive care unit admission	At 24 hours post intensive care unit admission	Metabolic parameters
Vital status at day 30	At 30 Days post intensive car unit admission	Alive or Dead status

Trial Locations

Locations (1)

Chu Grenoble Alpes; 🇫🇷 Grenoble, France