Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital

University Hospital, Grenoble1 site in 1 country40 target enrollmentJanuary 27, 2020

ConditionsCardiac Arrest

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cardiac Arrest
Sponsor: University Hospital, Grenoble
Enrollment: 40
Locations: 1
Primary Endpoint: Heart's respiratory value at H6 post intensive care unit admission to predict mortality
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

It has been shown that elevation of the heart's respiratory quotient after cardiac surgery is predictive of the complications occurrence. In addition, a high heart's respiratory quotient is predictive of anaerobic metabolism after cardiac surgery. In the wake of cardiorespiratory arrest, the presence of anaerobic metabolism reflected by hyperlactatemia is an important prognostic factor. However, this monitoring is invasive and discontinuous. The hypothesis of the study is to show that a rise in the respiratory quotient by a non-invasive monitoring is a factor of poor prognosis in the wake of a Cardiac Arrest.

Registry

clinicaltrials.gov

Start Date

January 27, 2020

End Date

September 22, 2023

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Grenoble

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Adult \>18 years
•Admission to intensive care unit after a non-hospital cardiopulmonary arrest.
•Resumption of spontaneous cardiac activity.
•Non-opposition of the patient or his relatives

Exclusion Criteria

•Pregnancy
•Prior neurological impairment
•Persons deprived of their liberty by a judicial proceeding, or administrative decision.

Outcomes

Primary Outcomes

Heart's respiratory value at H6 post intensive care unit admission to predict mortality

Time Frame: At 6 hours post intensive care unit admission

Physiological parameter

Secondary Outcomes

Heart's respiratory value at H24 post intensive care unit admission to predict mortality(At 24 hours post intensive care unit admission)
Heart's respiratory value at H12 post intensive care unit admission to predict mortality(At 12 hours post intensive care unit admission)
Heart's respiratory value at H6 post intensive care unit admission to predict neurological prognosis(At 6 hours post intensive care unit admission)
Heart's respiratory value at H12 post intensive care unit admission to predict neurological prognosis(At 12 hours post intensive care unit admission)
metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H6 post intensive care unit admission(At 6 hours post intensive care unit admission)
Heart's respiratory value at intensive care unit admission to predict neurological prognosis(At admission of intensive care unit)
Heart's respiratory value at H24 post intensive care unit admission to predict neurological prognosis(At 24 hours post intensive care unit admission)
metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at intensive care unit admission(At admission of intensive care unit)
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H6 post intensive care unit admission(At 6 hours post intensive care unit admission)
Heart's respiratory value at intensive care unit admission to predict mortality(At admission of intensive care unit)
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H12 post intensive care unit admission(At 12 hours post intensive care unit admission)
Cardiac arrest circumstances following Utstein-style guidelines according mortality(At admission of intensive care unit)
Cardiac arrest circumstances following Utstein-style guidelines according neurological prognosis(At admission of intensive care unit)
Cerebral performance category (CPC) score at day 90(At 90 Days post intensive car unit admission)
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H12 post intensive care unit admission(At 12 hours post intensive care unit admission)
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H24 post intensive care unit admission(At 24 hours post intensive care unit admission)
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at intensive care unit admission(At admission of intensive care unit)
Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H24 post intensive care unit admission(At 24 hours post intensive care unit admission)
Vital status at day 30(At 30 Days post intensive car unit admission)