Effect of Vitamin D3 on Cardiovascular Risk Factors: a Randomized Trial in Human
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 主要终点
- blood pressure
研究概览
简要总结
The aim of this study is to investigate whether a supplementation of Vitamin D3 can be used to reduce atherosclerotic risk factors.
详细描述
It is the objective of this study to investigate whether a supplementation with Vitamin D3 can be used to reduce atherosclerotic risk factors such as hypertension, inflammation and hyperlipidemia. The research question is whether Vitamin D3 can lower blood pressure in mildly hypertensive subjects who are naive to antihypertensive medication, whether Vitamin D reduces the level of systemic inflammation and whether Vitamin D3 has an effect on blood lipids.
major outcomes:
- decrease of systolic blood pressure in the treatment group in comparison with the placebo group
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •human volunteers with mild hypertension
排除标准
- •use of antihypertensive medication
- •use of vitamin d or calcium supplements
- •known renal, inflammatory or malignant diseases
- •hypercalcemia or hypercalciuria
- •participation in other clinical studies
- •use of tanning booths during the study
研究组 & 干预措施
Placebo
干预措施: Placebo (Dietary Supplement)
vitamin d
干预措施: Vitamin D3 (Dietary Supplement)
结局指标
主要结局
blood pressure
时间窗: after 8 weeks of supplementation
major outcome variable is the decrease oy systolic blood pressure in the treatment group in comparison with the placebo group.
次要结局
未报告次要终点
研究者
Ulf Schlegelmilch
Principal Investigator
Martin-Luther-Universität Halle-Wittenberg