Assessment of gastroesophageal reflex disease (GERD) with FSSG score in hemodialysis patients

Not Applicable

• Conditions: Gastroesophageal reflux disease (GERD) Chronic hemodialysis patients

• Registration Number: JPRN-UMIN000001907
• Lead Sponsor: Osaka University Hospital

Brief Summary

Results Their average age was 66 years (58-73), with average hemodialysis duration of 5 years. A positive FSSG result (score>=8) was recorded by 21 patients out of 167 subjects, indicating the existence of GERD, despite almost 80% of subjects already on Proton pump inhibitors, Histamine receptor 2 antagonists and/or Gastromucosal protective agent (GMP). To avoid the effect of advanced age upon gastroesophageal symptoms, we analyzed 112 hemodialysis patients under 70 years old. The average age was 62 years (56-66), with average hemodialysis duration of 7 years. 11.6% of hemodialysis patients under 70 yielded positive FSSG results (score>8). GMP use negatively correlated with the dysmotility score (p=0.013). Multivariate logistic regression analysis also confirmed that calcium channel blocker use, common in dialysis patients, correlated with the acid reflux score (p=0.042). No correlation was seen between endoscopic findings and FSSG scores. Conclusion 12.5% of hemodialysis patients yielded positive FSSG results (score>8), indicating the presence of GERD. The FSSG shows promise as a useful tool in the diagnosis of GERD in hemodialysis patients.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-04-25
• Study Completion: 2011-12-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Not provided

Exclusion Criteria

1) Patients with malignancy whose prognoses are predicted less than 6 months. 2) Patients with severe heart failure or hepatic failure. 3) Patients who have epigastric symptoms other than GERD. 4) Patients who have histories of renal transplantation.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Study 1) FSSG (Frequency scale for the symptom of GERD) scores and findings of gastrointestinal fiber (GIF). Study 2) Reduction in FSSG scores.

Secondary Outcome Measures

Name	Time	Method
Association between concomitant drugs and FSSG scores.