Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Assessment of postoperative pain levels
研究概览
简要总结
Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
详细描述
This study aims to evaluate postoperative pain levels and Substance P expression following the use of two different intracanal medicaments: bioceramic materials and calcium hydroxide in permanent mandibular molars diagnosed with symptomatic apical periodontitis.
A total of 28 patients will be included in this study and randomly allocated into two equal groups (n=14 each). Group I will receive calcium hydroxide (Ca(OH)₂) as an intracanal medicament, while Group II will receive a bioceramic intracanal medicament.
Standardized endodontic procedures will be performed for all participants. Postoperative pain will be assessed using a visual analog scale (VAS) at different time intervals following treatment.
In addition, samples will be collected to evaluate Substance P levels as a biochemical marker associated with pain and inflammation.
The comparison between the two groups will help determine the effectiveness of each intracanal medicament in reducing postoperative pain and inflammatory response. The results of this study may contribute to improving clinical decision-making in endodontic therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Patients aged 18-45 years with no sex predilection
- •Medically free Patients with no systemic conditions that can affect post operative pain response.
- •Patients should not be taking any pain medications 24 hours before intervention
- •Positive patients' acceptance for participating in the study
- •Patient able to sign informed consent
- •Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis
- •Permanent molars without any anatomical variations or severe curvatures
排除标准
- •- Medically compromised patients
- •Patients who have received antibiotic therapy within the last 2 weeks.
- •Pregnant or lactating women.
- •Patients with known allergy to any of the irrigants used.
- •Patients with swelling or acute peri-apical abscess or fistulous tract.
- •Teeth that have:
- •Wide or open apex .
- •Vital pulp tissue .
- •Periodontally affected with grade 2or 3 mobility.
- •Non restorable teeth .
- •Abnormal anatomy and calcified canals .
- •Pervious root canal treatment.
- •severe curved canal
- •Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy
研究组 & 干预措施
Bioceramic Group
Bio-C Temp Angelus
干预措施: Bioceramic Intracanal Medicament (Drug)
Calcium Hydroxide Group
Meta Paste (Meta Biomed)
干预措施: Calcium Hydroxide (Ca(OH)2) (Drug)
结局指标
主要结局
Assessment of postoperative pain levels
时间窗: one week
Postoperative pain intensity will be assessed using the Visual Analog Scale (VAS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Pain scores will be recorded at 6 hours, 24 hours, 48 hours, 72 hours, and 7 days after treatment to compare postoperative pain levels between the two medicament groups and evaluate the correlation between Substance P reduction and pain perception.
次要结局
- neurogenic biomarker Substance P Level(one week after the pulp Extirpation)
研究者
salma tarek abdullah
Principal Investigator
Future University in Egypt