Neural Predictors of Response to Cognitive Behavioral Therapy for Adolescent Depression
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Clinician-rated improvement
Study Overview
Brief Summary
The current study will examine neurophysiological, specifically event-related potential (ERP), measures of emotional processing as predictors of response to cognitive behavior therapy for adolescent depression.
Detailed Description
Neurophysiological measures (i.e., event-related potentials) of reward responsiveness and regulation of mood-congruent, sad stimuli will be assessed in a sample of adolescents with depression prior to group cognitive behavior therapy (CBT). CBT will follow the Adolescent Coping with Depression Course, an established 16-session group treatment protocol, and consist of behavioral activation, relaxation skills, cognitive therapy, social skills, problem solving, and relapse prevention. Changes in symptoms will be monitored through biweekly self-report and clinician ratings to examine prediction of change in symptoms across CBT. Baseline individual differences in reward responsiveness and emotion regulation will be evaluated as predictors of change in self-reported symptoms and clinician-rated improvement following CBT.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 14 Years to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Participants presenting with major depressive or persistent depressive disorder and moderate severity on the Clinical Global Impressions scale.
- •Participants may have comorbid externalizing or anxiety disorders.
- •Participants (and parents of minors) fluent in English.
Exclusion Criteria
- •Youth with history of treatment for substance use disorders.
- •Youth with intellectual or developmental disabilities (e.g., autism spectrum disorders, pervasive developmental disorders).
- •Youth with lifetime schizophrenia, psychosis, or mania.
- •Youth with severe current suicidality.
- •Youth taking antipsychotic medications or mood stabilizers.
- •Youth with recent changes in dosage of antidepressant (adolescents with change in dosage in past 30 days who otherwise meet study criteria will be asked to begin the study once dosage has been stable for 30 days).
- •Parent or child not fluent in English.
- •Youth who are unable to complete study procedures because of visual or hearing impairments.
- •Youth who have recently started outside therapy (past 30 days at time of intake), are engaged in treatment that is determined to be too similar to study therapy (e.g, other CBT groups), or are currently in treatment that is too intensive to allow for participation in study therapy (e.g., partial hospitalization programs)
Arms & Interventions
Active Treatment
Group cognitive behavioral therapy (CBT) for 8 weeks.
Intervention: Cognitive Behavioral Therapy (Behavioral)
Outcomes
Primary Outcomes
Clinician-rated improvement
Time Frame: 8 weeks
Global improvement rating on the Clinical Global Impression scale
Depressive symptoms
Time Frame: past 2 weeks
Self-reported symptoms on the Mood and Feelings Questionnaire
Secondary Outcomes
No secondary outcomes reported
Investigators
Autumn Kujawa
Assistant Professor
Vanderbilt University